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2.
Sensors (Basel) ; 23(14)2023 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-37514818

RESUMO

The motion of input material in a rotary kiln is an important aspect of its operation. This can be observed especially in the case of the implementation of the hazardous waste incineration process in this device. The values of the flow parameters, mainly the residence time and the degree of mixing, can determine the proper and safe treatment of waste. The relationships that occur in the layer of solid material in a rotary kiln have not been completely recognized. This article presents a research method that involves an experiment on a laboratory stand simulating a rotary kiln in association with a dedicated algorithm. Multi-criteria tests were carried out. The adopted research method was the tracer method. It used a tracer which, subject to the same transport conditions as other material particles, provided information on the characteristic of the motion of tested materials in the rotating cylinder. The application based on the residence time distribution (RTD) algorithm returned information about the characteristics of the motion of the material in the rotary cylinder in terms of residence time distribution and the degree of mixing. This tracer method, together with stimulus impulses on the grate and a dedicated RTD algorithm, was used here as a sensor method to examine the characteristics of material motion on various grate systems. The data obtained as a result of this research may include, among others, the boundary conditions for numerical simulations of processes carried out in a rotary kiln.

3.
Nutrients ; 15(5)2023 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-36904086

RESUMO

Medical nutrition should be tailored to cover a patient's needs, taking into account medical and organizational possibilities and obstacles. This observational study aimed to assess calories and protein delivery in critically ill patients with COVID-19. The study group comprised 72 subjects hospitalized in the intensive care unit (ICU) during the second and third SARS-CoV-2 waves in Poland. The caloric demand was calculated using the Harris-Benedict equation (HB), the Mifflin-St Jeor equation (MsJ), and the formula recommended by the European Society for Clinical Nutrition and Metabolism (ESPEN). Protein demand was calculated using ESPEN guidelines. Total daily calorie and protein intakes were collected during the first week of the ICU stay. The median coverages of the basal metabolic rate (BMR) during day 4 and day 7 of the ICU stay reached: 72% and 69% (HB), 74% and 76% (MsJ), and 73% and 71% (ESPEN), respectively. The median fulfillment of recommended protein intake was 40% on day 4 and 43% on day 7. The type of respiratory support influenced nutrition delivery. A need for ventilation in the prone position was the main difficulty to guarantee proper nutritional support. Systemic organizational improvement is needed to fulfill nutritional recommendations in this clinical scenario.


Assuntos
COVID-19 , Humanos , Estado Terminal/terapia , SARS-CoV-2 , Apoio Nutricional , Estado Nutricional , Proteínas
4.
Diagnostics (Basel) ; 13(4)2023 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-36832241

RESUMO

Fifty-four-year old male was admitted to the intensive care unit (ICU) due to impaired consciousness. Past medical history included alcohol dependence, liver cirrhosis, esophageal varices, 2 esophageal varices banding procedures in the past, pathological obesity. Computed tomography (CT) examination of the head performed in the referring hospital was normal. At admission the CT examination of the head was repeated and showed no abnormalities. Urgent esophagogastroduodenoscopy revealed presence of esophageal varices and scarification following previous banding procedures located in the middle and lower part of the esophagus. Gastrointestinal bleeding being the most likely cause of chronic liver decompensation was therefore excluded. Multimodal neurologic diagnostic assessment was negative. Finally magnetic resonance imaging (MRI) of the head was performed. Taking into account clinical picture and the MRI result, the differential diagnosis included chronic liver encephalopathy, exacerbated acquired hepatocerebral degeneration, and acute liver encephalopathy. Due to history of umbilical hernia CT of the abdomen and pelvis was performed and showed intussusception of the ileum, confirming hepatic encephalopathy. In this case report the MRI suggested the diagnosis of hepatic encephalopathy and prompted search for alternative causes of decompensation of chronic liver disease.

5.
Neurosci Lett ; 784: 136744, 2022 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-35718239

RESUMO

Synaptic dysfunction is the prominent feature of many neuropsychiatric and neurological diseases, in which glycogen synthase kinase 3ß (GSK-3ß) has been shown to play a role. Overexpression of constitutively active form of GSK-3ß (GSK-3ß[S9A]) in mice recapitulates the cognitive and structural brain deficits characteristic for manic phase of bipolar disorder (BD). Yet, the mechanisms underlying GSK-3ß-induced synaptic dysfunction have not been fully elucidated. The aim of the present study was to dissect the effect of GSK-3ß overactivity on synaptic function in adolescent (3-week-old) mice. We found that overactivity of GSK-3ß in adolescent transgenic mice leads to an alteration in dendritic spines morphology of granule cells in dentate gyrus (DG) without changes in overall spine density. There was an increase in the number of thin, presumably immature dendritic spines in GSK-3ß[S9A] mice. Subsequent electrophysiological analysis showed changes in excitatory synaptic transmission manifested by an increase of inter-event intervals of miniature excitatory postsynaptic currents (mEPSCs) in DG granule cells and an increase in the number of silent (unfunctional) synapses at the perforant path-DG pathway in GSK-3ß[S9A] mice. Altogether, our data indicate that GSK-3ß overactivity leads to synaptic deficits in adolescent, GSK-3ß[S9A] mice. These data might provide potential mechanisms underlying GSK-3ß-induced synaptic dysfunction in psychiatric disorders.


Assuntos
Espinhas Dendríticas , Glicogênio Sintase Quinase 3 beta , Neurônios , Animais , Glicogênio Sintase Quinase 3 beta/metabolismo , Camundongos , Camundongos Transgênicos , Neurônios/metabolismo , Sinapses
6.
Mol Phylogenet Evol ; 173: 107527, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35577286

RESUMO

Recent progress in the taxonomy of flat bark beetles (Cucujidae), specifically, in the genus Cucujus, has revealed great diversity in subtropical Asia, but the seemingly well-known temperate and boreal taxa need further attention because of their conservation status. Here, we used an integrative approach using morphology, DNA, and species distribution modelling to disentangle phylogenetic relations, verify the number of species, and understand the historical biogeography of Palearctic and Nearctic Cucujus beetles, particularly the C. haematodes species group. Species distinctiveness was supported for C. cinnaberinus, but present-day C. haematodes turned out to be a species complex made up of separate lineages in the western, middle and eastern parts of its Palearctic range. Cucujus muelleri was a member of that complex, being sister to Asian C. haematodes. Moreover, C. haematodes caucasicus was found to be phylogenetically closely related to Italian C. tulliae, and both to be sister to European C. haematodes. North American C. clavipes clavipes and C. c. puniceus resulted to be enough divergent to be considered different species. Interestingly, western American C. puniceus turned out to be closely related to the C. haematodes complex, whereas eastern American C. clavipes constituted a separate lineage, being distantly related to both C. puniceus and C. cinnaberinus. These patterns suggest former trans-continental connections among the ancestors of extant flat bark beetle species. Moreover, a divergent lineage of C. cinnaberinus was found in Calabria, which should be regarded at the very least as a subspecies. The ancestor of C. hameatodes group originated in mid-Miocene, and next, ca. 6.2 Mya, a line leading to C. cinnaberinus had split. Speciation of the American lineages occurred during Pliocene (4.4 Mya for C. clavipes and 3.3 Mya for C. puniceus). Species classified as C. haematodes, C. tulliae and C. muelleri, as well as distinct lineages within C. cinnaberinus split during mid Pleistocene (ca. 1.5 Mya). A comparison of species climatic requirements and their present distribution allowed to identify glacial refugia in south-eastern areas of North America (C. clavipes), south-western areas of North America (C. puniceus), and the Mediterranean and Caspian Sea Basins (European Cucujus species), or south-eastern areas of Asia and the foothills of the central Asian mountains (eastern C. haematodes). Subsequent climatic changes in the Holocene forced these beetles to move their ranges northwards along the coasts of the Pacific (C. puniceus) or Atlantic (C. clavipes), north-eastwards to central, northern, and eastern Europe (C. cinnaberinus and European C. haematodes) or Siberia (Asian C. haematodes). The combined use of molecular, morphological and climatic data allows a comprehensive understanding of the phylogenetic relations and past distributions of Cucujus beetles, highlighting the complexity of C. haematodes species group evolution.


Assuntos
Besouros , Animais , Ásia , Besouros/genética , América do Norte , Filogenia , Refúgio de Vida Selvagem
7.
Insects ; 13(3)2022 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-35323518

RESUMO

Black pheromone-baited traps are commonly used for monitoring Monochamus galloprovincialis, a vector of Bursaphelenchus xylophilus, although few studies have been conducted on its response to color (black, white, and clear). The objective of our studies was to evaluate the attractiveness of different colors to M. galloprovincialis and non-target species: Spondylis buprestoides and predatory Thanasimus formicarius and T. femoralis. Laboratory tests of fifteen colors against immature and mature M. galloprovincialis revealed some differences in their color preference. In two field tests, eight colors of coroplast vanes in cross-vane traps were compared with unpainted white (a reference (RF)). The first test confirmed the laboratory results, i.e., RF was slightly more attractive to M. galloprovincialis than pastel yellow, reseda green, and cyan blue, but trap color had no significant effect on any of the insect species studied. In the second test, the attractiveness of RF was highest and significantly different from pure white (for all four species), light blue, and pine green (except S. buprestoides). Overall, the unpainted white traps appeared to be most effective in catching M. galloprovincialis. Thanasimus spp. responded to the colors similarly to M. galloprovincialis; therefore, either trap design or lure composition should be modified to reduce their catches.

8.
Neuroscience ; 490: 287-295, 2022 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-35331845

RESUMO

Glycogen synthase kinase-3ß (GSK-3ß) is a highly expressed kinase in the brain, where it has an important role in synaptic plasticity. Aberrant activity of GSK-3ß leads to synaptic dysfunction which results in the development of several neuropsychiatric and neurological diseases. Notably, overexpression of constitutively active form of GSK-3ß (GSK-3ß[S9A]) in mice recapitulates the cognitive and structural defects characteristic for neurological and psychiatric disorders. However, the mechanisms by which GSK-3ß regulates synaptic functions are not clearly known. Here, we investigate the effects of GSK-3ß overactivity on neuronal miRNA expression in the mouse hippocampus. We found that GSK-3ß overactivity downregulates miRNA network with a potent effect on miR-221-5p (miR-221*). Next, characterization of miR-221* function in primary hippocampal cell culture transfected by miR-221* inhibitor, showed no structural changes in dendritic spine shape and density. Using electrophysiological methods, we found that downregulation of miR-221* increases excitatory synaptic transmission in hippocampal neurons, probably via postsynaptic mechanisms. Thus, our data reveal potential mechanism by which GSK-3ß and miRNAs might regulate synaptic function and therefore also synaptic plasticity.


Assuntos
Glicogênio Sintase Quinase 3 beta , MicroRNAs , Plasticidade Neuronal , Animais , Glicogênio Sintase Quinase 3 beta/metabolismo , Hipocampo/metabolismo , Camundongos , MicroRNAs/metabolismo , Neurônios/metabolismo
9.
Sensors (Basel) ; 22(3)2022 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-35161614

RESUMO

The paper presents experimental research on hydrodynamic forces generated on a ship moored at a long quay wall, modeling the solid-type berth, by a passing ship. The proper prediction of interactions between the moored and passing ships is important for design and operational purposes. The results of the presented parametric study are presented as a space-time series of the forces as the functions of passing ship velocity and transverse separation distance between the ships. The experimental test setup constructed on the lake and the large scale of the manned physical ship models enabled a simulation of the real maneuvering situation. The force measurements were taken on the moored ship model fixed to the pantographs rigidly attached to the wall. The twin pantographs were attached to force sensors on the deck of the model by a system of movable joints, enabling the measurement of surge and sway forces. The presented method was verified based on available experimental and numerical data, showing a good agreement with the results.

10.
Ecol Appl ; 32(2): e2516, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34918844

RESUMO

Natural disturbances are increasing around the globe, also impacting protected areas. Although previous studies have indicated that natural disturbances result in mainly positive effects on biodiversity, these analyses mostly focused on a few well established taxonomic groups, and thus uncertainty remains regarding the comprehensive impact of natural disturbances on biodiversity. Using Malaise traps and meta-barcoding, we studied a broad range of arthropod taxa, including dark and cryptic taxa, along a gradient of bark beetle disturbance severities in five European national parks. We identified order-level community thresholds of disturbance severity and classified barcode index numbers (BINs; a cluster system for DNA sequences, where each cluster corresponds to a species) as negative or positive disturbance indicators. Negative indicator BINs decreased above thresholds of low to medium disturbance severity (20%-30% of trees killed), whereas positive indicator BINs benefited from high disturbance severity (76%-98%). BINs allocated to a species name contained nearly as many positive as negative disturbance indicators, but dark and cryptic taxa, particularly Diptera and Hymenoptera in our data, contained higher numbers of negative disturbance indicator BINs. Analyses of changes in the richness of BINs showed variable responses of arthropods to disturbance severity at lower taxonomic levels, whereas no significant signal was detected at the order level due to the compensatory responses of the underlying taxa. We conclude that the analyses of dark taxa can offer new insights into biodiversity responses to disturbances. Our results suggest considerable potential for forest management to foster arthropod diversity, for example by maintaining both closed-canopy forests (>70% cover) and open forests (<30% cover) on the landscape.


Assuntos
Artrópodes , Besouros , Animais , Biodiversidade , Florestas , Casca de Planta
11.
Sensors (Basel) ; 21(21)2021 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-34770551

RESUMO

The amount of generated waste, which increases every year, is a serious problem of the modern world. In particular, attention should be paid to hazardous waste and methods of its disposal. One of the most used in this context is thermal treatment in dedicated incinerators equipped with a rotary kiln. Conducting the process requires, inter alia, supplying the furnace with a batch of batch material with appropriate parameters. Improper operation in this regard may cause negative environmental effects and operational problems. The key here is to select different types of hazardous waste and compose batch portions. The paper presents an application that optimizes the work of waste incineration plant operators. At the same time, this tool can be described as ensuring security at this stage of the process. The application implements an ant colony algorithm that selects the optimal solution to the problem, which has been formulated here as the types and masses of the batch mixture components with given parameters. The application has been tested in the laboratory and real conditions with satisfactory results.


Assuntos
Resíduos Perigosos , Incineração , Algoritmos , Resíduos Perigosos/análise , Heurística
12.
Sensors (Basel) ; 21(18)2021 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-34577375

RESUMO

The presented paper proposes a hybrid neural architecture that enables intelligent data analysis efficacy to be boosted in smart sensor devices, which are typically resource-constrained and application-specific. The postulated concept integrates prior knowledge with learning from examples, thus allowing sensor devices to be used for the successful execution of machine learning even when the volume of training data is highly limited, using compact underlying hardware. The proposed architecture comprises two interacting functional modules arranged in a homogeneous, multiple-layer architecture. The first module, referred to as the knowledge sub-network, implements knowledge in the Conjunctive Normal Form through a three-layer structure composed of novel types of learnable units, called L-neurons. In contrast, the second module is a fully-connected conventional three-layer, feed-forward neural network, and it is referred to as a conventional neural sub-network. We show that the proposed hybrid structure successfully combines knowledge and learning, providing high recognition performance even for very limited training datasets, while also benefiting from an abundance of data, as it occurs for purely neural structures. In addition, since the proposed L-neurons can learn (through classical backpropagation), we show that the architecture is also capable of repairing its knowledge.


Assuntos
Análise de Dados , Aprendizado de Máquina , Redes Neurais de Computação , Neurônios , Reconhecimento Psicológico
13.
Sci Total Environ ; 791: 148159, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34119779

RESUMO

Human-induced climate and land-use changes are important factors influencing global insect diversity. Nevertheless, the influence of weather on biodiversity is still relatively rarely studied. Grassland insects may be the taxon that is most affected by changing weather. We focused on the influence of weather and land-use management on butterflies in hayed meadows in the Czech Republic. During two consecutive years (2019-2020), we studied nearly 300 independent meadows. The abundance of butterflies was more influenced by the weather than their species richness. We observed positive and mainly linear effects of increasing vegetation temperatures. One very influential variable was the light intensity, which had a nonlinear effect that promoted butterflies under direct sunlight. The humidity had mainly moderate, nonlinear effects. Surprisingly, the wind had only a small effect. We observed important effects of the flowering intensity and vegetation height on the butterfly species richness and abundance regarding land use. Marginal woody vegetation cover had a positive effect on the butterfly abundance, and management had little effect. We concluded that weather and land use had important effects on butterflies. Based on our research, we recommended the reconsideration of scientific studies and monitoring programs for insects concerning the temperature threshold (≥ 25 °C) and the consideration of light intensity as an important factor. Applying a detailed approach to measuring the flowering intensity is likely unnecessary, while meadow land-use parameters appear to be necessary for insect populations.


Assuntos
Borboletas , Agricultura , Animais , Biodiversidade , Ecossistema , Humanos , Insetos
14.
Curr Biol ; 31(11): 2347-2358.e6, 2021 06 07.
Artigo em Inglês | MEDLINE | ID: mdl-33848461

RESUMO

Animals display a rich repertoire of defensive responses adequate to the threat proximity. In social species, these reactions can be additionally influenced by the behavior of fearful conspecifics. However, the majority of neuroscientific studies on socially triggered defensive responses focuses on one type of behavior, freezing. To study a broader range of socially triggered reactions and underlying mechanisms, we directly compared two experimental paradigms, mimicking occurrence of the imminent versus remote threat. Observation of a partner currently experiencing aversive stimulation evokes passive defensive responses in the observer rats. Similar interaction with a partner that has just undergone the aversive stimulation prompts animals to increase active exploration. Although the observers display behaviors similar to those of the aversively stimulated demonstrators, their reactions are not synchronized in time, suggesting that observers' responses are caused by the change in their affective state rather than mimicry. Using opsins targeted to behaviorally activated neurons, we tagged central amygdala (CeA) cells implicated in observers' responses to either imminent or remote threat and reactivated them during the exploration of a novel environment. The manipulation revealed that the two populations of CeA cells promote passive or active defensive responses, respectively. Further experiments confirmed that the two populations of cells at least partially differ in expression of molecular markers (protein kinase C-δ [PKC-δ] and corticotropin-releasing factor [CRF]) and connectivity patterns (receiving input from the basolateral amygdala or from the anterior insula). The results are consistent with the literature on single subjects' fear conditioning, suggesting that similar neuronal circuits control defensive responses in social and non-social contexts.


Assuntos
Complexo Nuclear Basolateral da Amígdala , Núcleo Central da Amígdala , Animais , Antígeno Carcinoembrionário , Hormônio Liberador da Corticotropina , Medo , Ratos
15.
Sensors (Basel) ; 20(17)2020 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-32854356

RESUMO

This paper presents a novel approach to a complex process of electrical capacitance tomography (ECT) measurement data analysis. ECT is frequently employed for non-invasive monitoring of industrial process phenomena. Proposed methodology is based on the premeditated integration of the spatial and temporal relations inherent in the measurement records into the workflow of the analysis procedure. We propose a concept of interactive timeline that enables arranging data visualization according to the user's current focus along the process of analysis. We evaluated the proposed method using a prototype system in a task-based user study conducted with a group of domain experts. The evaluation is based on gravitational silo flow measurement datasets. Proposed prototype system enables diverse data manipulation in a more natural way allowing the user to switch back and forth between space and time domains along the data analysis trail. Experiments with the prototype system showed that the accuracy and completion times have significantly improved in comparison to the performance measured in the baseline condition. Additionally, the participants reported decreased physical load with improved efficiency measured with NASA task load index. Finally, a short discussion coupled with directions for the future of interactive spatio-temporal ECT measurement data analysis conclude the paper.

16.
Artigo em Inglês | MEDLINE | ID: mdl-32630399

RESUMO

Treatment with osmoactive agents such as mannitol or hypertonic saline (HTS) solutions is widely used to manage or prevent the increase of intracranial pressure (ICP) in central nervous system (CNS) disorders. We sought to evaluate the variability and mean plasma concentrations of the water and electrolyte balance parameters in critically ill patients treated with osmotic therapy and their influence on mortality. This cohort study covered patients hospitalized in an intensive care unit (ICU) from January 2017 to June 2019 with presumed increased ICP or considered to be at risk of it, treated with 15% mannitol (G1, n = 27), a combination of 15% mannitol and 10% hypertonic saline (HTS) (G2, n = 33) or 10% HTS only (G3, n = 13). Coefficients of variation (Cv) and arithmetic means (mean) were calculated for the parameters reflecting the water and electrolyte balance, i.e., sodium (NaCv/NaMean), chloride (ClCv/ClMean) and osmolality (mOsmCv/mOsmMean). In-hospital mortality was also analyzed. The study group comprised 73 individuals (36 men, 49%). Mortality was 67% (n = 49). Median NaCv (G1: p = 0.002, G3: p = 0.03), ClCv (G1: p = 0.02, G3: p = 0.04) and mOsmCv (G1: p = 0.001, G3: p = 0.02) were higher in deceased patients. NaMean (p = 0.004), ClMean (p = 0.04), mOsmMean (p = 0.003) were higher in deceased patients in G3. In G1: NaCv (AUC = 0.929, p < 0.0001), ClCv (AUC = 0.817, p = 0.0005), mOsmCv (AUC = 0.937, p < 0.0001) and in G3: NaMean (AUC = 0.976, p < 0.001), mOsmCv (AUC = 0.881, p = 0.002), mOsmMean (AUC = 1.00, p < 0.001) were the best predictors of mortality. The overall mortality prediction for combined G1+G2+G3 was very good, with AUC = 0.886 (p = 0.0002). The mortality of critically ill patients treated with osmotic agents is high. Electrolyte disequilibrium is the independent predictor of mortality regardless of the treatment method used. Variations of plasma sodium, chloride and osmolality are the most deleterious factors regardless of the absolute values of these parameters.


Assuntos
Lesões Encefálicas , Hipertensão Intracraniana , Pressão Intracraniana/efeitos dos fármacos , Solução Salina Hipertônica/uso terapêutico , Estudos de Coortes , Feminino , Humanos , Hipertensão Intracraniana/tratamento farmacológico , Hipertensão Intracraniana/mortalidade , Masculino , Equilíbrio Hidroeletrolítico
17.
Biochim Biophys Acta Mol Cell Res ; 1867(9): 118745, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32450268

RESUMO

Glycogen synthase kinase 3beta (GSK-3ß) is an enzyme with a variety of cellular functions in addition to the regulation of glycogen metabolism. In the central nervous system, different intracellular signaling pathways converge on GSK-3ß through a cascade of phosphorylation events that ultimately control a broad range of neuronal functions in the development and adulthood. In mice, genetically removing or increasing GSK-3ß cause distinct functional and structural neuronal phenotypes and consequently affect cognition. Precise control of GSK-3ß activity is important for such processes as neuronal migration, development of neuronal morphology, synaptic plasticity, excitability, and gene expression. Altered GSK-3ß activity contributes to aberrant plasticity within neuronal circuits leading to neurological, psychiatric disorders, and neurodegenerative diseases. Therapeutically targeting GSK-3ß can restore the aberrant plasticity of neuronal networks at least in animal models of these diseases. Although the complete repertoire of GSK-3ß neuronal substrates has not been defined, emerging evidence shows that different ion channels and their accessory proteins controlling excitability, neurotransmitter release, and synaptic transmission are regulated by GSK-3ß, thereby supporting mechanisms of synaptic plasticity in cognition. Dysregulation of ion channel function by defective GSK-3ß activity sustains abnormal excitability in the development of epilepsy and other GSK-3ß-linked human diseases.


Assuntos
Fenômenos Eletrofisiológicos , Glicogênio Sintase Quinase 3 beta/genética , Glicogênio Sintase Quinase 3 beta/metabolismo , Neurônios/fisiologia , Animais , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Ondas Encefálicas , Modelos Animais de Doenças , Suscetibilidade a Doenças , Desenvolvimento de Medicamentos , Epilepsia/diagnóstico , Epilepsia/tratamento farmacológico , Epilepsia/etiologia , Epilepsia/metabolismo , Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores , Humanos , Canais Iônicos/metabolismo , Terapia de Alvo Molecular , Transdução de Sinais
18.
Zool Stud ; 59: e3, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32215060

RESUMO

Open habitats are disappearing from European forests. This is mainly due to various management-related practices, such as afforestation and the maintenance of closed canopy plantation forests. Open forests are also declining as a result of the abandonment of traditional forest use practices and natural succession. The effects of the establishment and maintenance of power lines as highly artificial but open habitats in forests on native insect biodiversity remain relatively poorly investigated. We investigated differences in biodiversity between forests and open habitats under power lines in Poland. Namely, we focused on nine insect taxa using the most suitable methods for data collection, i.e., observation and trapping. The studied habitats were forests used for timber production dominated by Scots pine, which is the most commercially important tree species in Poland. In total, we recorded the presence of more than 400 insect species. We found that butterflies as well as ground beetles were significantly more biodiverse under the power lines compared with the forest interior. Furthermore, jewel beetles, long-horned beetles, weevils and bark beetles, rove beetles and darkling beetles appeared to be more species rich under the power lines, click beetles were indifferent, and only lady-bird beetles appeared to be more abundant in forests. Additionally, ground beetles with a strict affinity for forests were surprisingly not negatively affected by power lines. We highlighted the importance of forest-free areas under power lines for the improvement of native forest biodiversity. Artificial and relatively intensive management activities related to the distribution of electric energy play important roles in creating novel or alternative habitats for many insects. Our paper contributes much to the knowledge about the importance of artificial open areas for the diversity of insects.

19.
Neural Plast ; 2019: 4209475, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31191636

RESUMO

In neurons, Glycogen Synthase Kinase-3ß (GSK-3ß) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity. Mouse models with neuron-selective expression or deletion of GSK-3ß present behavioral and cognitive abnormalities, positioning this protein kinase as a key signaling molecule in normal brain functioning. Furthermore, mouse models with defective GSK-3ß activity display distinct structural and behavioral abnormalities, which model some aspects of different neurological and neuropsychiatric disorders. Equalizing GSK-3ß activity in these mouse models by genetic or pharmacological interventions is able to rescue some of these abnormalities. Thus, GSK-3ß is a relevant therapeutic target for the treatment of many brain disorders. Here, we provide an overview of how GSK-3ß is regulated in physiological synaptic plasticity and how aberrant GSK-3ß activity contributes to the development of dysfunctional synaptic plasticity in neuropsychiatric and neurodegenerative disorders.


Assuntos
Glicogênio Sintase Quinase 3 beta/metabolismo , Degeneração Neural/metabolismo , Doenças Neurodegenerativas/metabolismo , Plasticidade Neuronal/fisiologia , Neurônios/metabolismo , Animais , Humanos , Camundongos , Degeneração Neural/patologia , Doenças Neurodegenerativas/patologia , Neurônios/patologia , Fosforilação
20.
J Crit Care ; 53: 87-90, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31202163

RESUMO

PURPOSE: We aimed to investigate sleep quality (SQ), daytime sleepiness (DS), and their relation with subject- and work-related factors among Polish anaesthesiologists. METHODS: The study group comprised 786 anaesthesiologists. The Sleep Quality Scale (SQS) was applied in order to assess SQ, while excessive DS was evaluated using the Epworth Sleepiness Scale (ESS). RESULTS: The median score on the SQS was 31 (IQR 27-35) points. The median score on the ESS was 17 (IQR 13-20) points, with mild-to-moderate excessive DS found in 260 (33.1%) and severe excessive DS among 478 (60.8%) of those surveyed. Worse SQ was found in females; smokers; those who suffered from any chronic diseases; those who were receiving medication interfering with sleeping habits; those who were unsatisfied with their sleep; those who had a greater number of night shifts; and those who had a lower number of non-working days. A detrimental sleepiness pattern was determined by one's advanced age, the presence of any chronic diseases and lower satisfaction with one's sleep quantity. CONCLUSION: Poor SQ and excessive DS are frequently occurring phenomena. Since sleep disturbances are also related to the nature of their profession, the problem could be reduced by introducing organisational changes at work.


Assuntos
Anestesiologistas/estatística & dados numéricos , Cuidados Críticos/estatística & dados numéricos , Distúrbios do Sono por Sonolência Excessiva/psicologia , Doenças Profissionais/psicologia , Sono/fisiologia , Adulto , Anestesiologistas/psicologia , Cuidados Críticos/psicologia , Distúrbios do Sono por Sonolência Excessiva/etnologia , Distúrbios do Sono por Sonolência Excessiva/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/etnologia , Doenças Profissionais/fisiopatologia , Satisfação Pessoal , Inabilitação do Médico/psicologia , Inabilitação do Médico/estatística & dados numéricos , Polônia/etnologia , Inquéritos e Questionários , Tolerância ao Trabalho Programado/fisiologia , Local de Trabalho/organização & administração
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